Canadian Spine Outcomes and Research Network (CSORN) Sub-Study: Surgical Treatment of Adult Spinal Deformity
Principal Investigator: Dr. Alex Soroceanu
Study Objectives:
• To identify if significant regional variation occurs in the referral pattern and surgical treatment of adult spinal deformity patients in Canada.
• To determine if specific variables independently predict the clinical outcome of surgical intervention for adult spinal deformity.
• To determine if specific variables independently predict adverse events associated with adult spinal deformity surgery.
• To determine if specific variables independently predict the radiographic outcome of surgical intervention for adult spinal deformity.
Canadian Spine Outcomes and Research Network (CSORN) sub-study: Cervical Spondylotic Myelopathy
Principal Investigators: Dr. Nicolas Dea and Dr. Nathan Evaniew
Study Objectives:
• To determine the natural history of CSM patients selected for conservative management based on mild non progressive symptoms or patients preference not to undergo surgery
• To determine the outcomes of patients decompressed anteriorly, posteriorly and with a combined anterior/posterior approach.
• To determine differences in outcome for patients undergoing laminectomy and fusion (LF) versus laminoplasty (LP) for multi-level CSM based on a Standardized Clinical Assessment and Management Plan (SCAMP)
• To perform cost-utility analysis for different surgical and non-surgical management strategies for CSM
Canadian Spine Outcomes and Research Network (CSORN) Sub-Study: Surgical Treatment of Degenerative Spondylolisthesis: A Standardized Clinical Assessment and Management Plan (SCAMPS) Canadian Spine Society (CSS) Multicentre Prospective Cohort Study
Principal Investigators: Dr. Raja Rampersaud, Dr. Charles Fisher, Dr. R Andrew Glennie, Dr. Chris Bailey
Study Objectives:
• A prospective observational study aiming to classify surgical techniques for the management of degenerative spondylolisthesis based on the stability of the pathology.
Pediatric Spine Sub Study: PERFORM.
Study Objectives:
•This multicentre Canadian study will prospectively enrol pediatric patients with spinal pathology requiring surgical treatment. The objective of the PERFORM sub-study is to track specific outcome measures of different surgical techniques. Data collection will be comprised primarily of pediatric participant and physician reported outcomes.
Decompression Alone vs. Decompression and Instrumented Fusion for the Management of Lumbar Spinal Stenosis Associated with Stable Degenerative Spondylolisthesis: A Pragmatic Randomized Clinical Pilot Trial
Study Objectives:
•To assess the feasibility of a randomized controlled trial comparing MSDA to usual care (decompression with fusion) for stable DLS with respect to patient recruitment, effectiveness of randomization and patient blinding. To determine if MSDA is non-inferior to usual care (decompression and fusion). To determine the variability of outcome in MSDA surgery for sample size determination. To collect preliminary data on health-related quality of life, pain, and patient costs associated with MSDA for stable DLS
Study Status: Closed 2020