Indirect decompression in the Surgical Treatment of Degenerative Spondylolisthesis: a multicenter prospective matched cohort study (sub-study of the CSORN DLS prospective cohort study named: Surgical Treatment of Degenerative Spondylolisthesis: A Standardized clinical assessment and management plan (SCAMPS) Canadian Spine Society (CSS) multicenter prospective cohort study)
Principal Investigator: Dr. Philippe Phan
Study Objectives:
The primary objective of this study is to obtain data from 2-year post-operative disease-specific questionnaires such as the Oswestry Disability Index (ODI) and generic health related quality of life (SF-12), patient reported outcomes (PROs) of patients with DLS. This data will help validate the clinical utility of the DSIC scheme in guiding the treatment for DLS patients using already established and well-recognized surgical techniques for their treatment compared to current care. We hypothesize that the data derived from questionnaires will guide physicians to stray away from performing decompression and fusion surgery on all DLS patients. This would ultimately result in better overall outcomes by equivalence in PROs and improved cost-utility from a societal perspective.
Anterior vs posterior surgery for lumbar isthmic spondylolisthesis: multicenter prospective cohort study
Principal Investigator: Dr. Charolotte Dandurand
Study Objectives:
This study will involve multiple phases to answer specific research questions comparing the standard of care procedures, anterior to posterior interbody fusion in patients with isthmic spondylolisthesis.
• The primary end point will be 1-year proportions of patients reaching minimal clinically important difference (MCID) in terms of leg pain measured by NRS leg.
• The secondary endpoint will be occurrence of predetermined moderate to severe AEs, reoperations for nonunion or adjacent segment disease, radiological alignment correction and correlation with HRQOL.
Canadian Spine Outcomes and Research Network (CSORN) Sub-Study: Surgical Treatment of Adult Spinal Deformity
Principal Investigator: Dr. Alex Soroceanu
Study Objectives:
• To identify if significant regional variation occurs in the referral pattern and surgical treatment of adult spinal deformity patients in Canada.
• To determine if specific variables independently predict the clinical outcome of surgical intervention for adult spinal deformity.
• To determine if specific variables independently predict adverse events associated with adult spinal deformity surgery.
• To determine if specific variables independently predict the radiographic outcome of surgical intervention for adult spinal deformity.
Canadian Spine Outcomes and Research Network (CSORN) sub-study: Cervical Spondylotic Myelopathy
Principal Investigators: Dr. Nicolas Dea and Dr. Nathan Evaniew
Study Objectives:
• To determine the natural history of CSM patients selected for conservative management based on mild non progressive symptoms or patients preference not to undergo surgery
• To determine the outcomes of patients decompressed anteriorly, posteriorly and with a combined anterior/posterior approach.
• To determine differences in outcome for patients undergoing laminectomy and fusion (LF) versus laminoplasty (LP) for multi-level CSM based on a Standardized Clinical Assessment and Management Plan (SCAMP)
• To perform cost-utility analysis for different surgical and non-surgical management strategies for CSM
Canadian Spine Outcomes and Research Network (CSORN) Sub-Study: Surgical Treatment of Degenerative Spondylolisthesis: A Standardized Clinical Assessment and Management Plan (SCAMPS) Canadian Spine Society (CSS) Multicentre Prospective Cohort Study
Principal Investigators: Dr. Raja Rampersaud, Dr. Charles Fisher, Dr. R Andrew Glennie, Dr. Chris Bailey
Study Objectives:
• A prospective observational study aiming to classify surgical techniques for the management of degenerative spondylolisthesis based on the stability of the pathology.
Decompression Alone vs. Decompression and Instrumented Fusion for the Management of Lumbar Spinal Stenosis Associated with Stable Degenerative Spondylolisthesis: A Pragmatic Randomized Clinical Pilot Trial
Study Objectives:
•To assess the feasibility of a randomized controlled trial comparing MSDA to usual care (decompression with fusion) for stable DLS with respect to patient recruitment, effectiveness of randomization and patient blinding. To determine if MSDA is non-inferior to usual care (decompression and fusion). To determine the variability of outcome in MSDA surgery for sample size determination. To collect preliminary data on health-related quality of life, pain, and patient costs associated with MSDA for stable DLS
Study Status: Closed 2020